I am using Behind NAT Device with two Interfaces scenario. The external Interface is load Balanced using the F5. Internal Interface has no F5 so I am more concerned about the VIP is created on the external Interface of F5.
Eg. DA Servers External Network is 10.20.2.41, 10.20.2.41 and internal as 10.20.4.41, 10.20.4.42. After the Wizard, the first Server is 10.20.2.45, 10.20.2.42 on external with the VIP as 10.20.2.41 and Internal is 10.20.4.45, 10.20.4.42 and VIP as 10.20.4.41 which I am NOT really concerned about. My main concern is the DirectAccess's external interface where the IPHTTPS Tunnel terminates. I am using Performance L4 Profile. You can follow the question here...I do not want to bother the main guy who started this thread.. :)
https://devcentral.f5.com/questions/iphttps-with-directaccess-not-working-with-f5