FWIW, I had no issues upgrading from 6.0.2 to 6.0.3.
On the other hand, I had major headaches after installing Hotfix 2.1-1 for 6.0.3 after we had begun widely deploying the stand-alone F5 Networks VPN Client. That problem was due to our restrictive pre-logon inspection which requires a URI landing and the fact that the stand-alone client connects to the Firepass without any landing after updating itself. It also added a controller to the client's controller list, even though the Firepass configuration is set to have the client controller list match what is set in the Firepass. I've got a CR on this and apparently it will be resolved at some future time.
If you use the stand-alone client I highly recommend testing first if at all possible.