iRule for matching 2 x Data-groups

Nothing too complex. A nested IF-condition will do.

when HTTP_REQUEST {

  if { [class match [string tolower [HTTP::uri]] eq "Allowed-URIs" ] }{
    if { [class match [IP::client_addr] eq "Allowed-IPs" ] }{
       Do not interfere (Allowed)
      return
    } else {
       Not allowed
      drop
    }
  }

}

If you're going to use my solution, check to make sure that your Allowed-URIs definitions are all lower-case (or just remove the 'string tolower' function if you need case-sensitive matching).