iRule to catch 4XX and 5XX HTTP error codes.

Here is what I have used in the past to have the LTM try all members in the pool on a 4xx or 5xx status code. It could be easy updated to do what you want

when CLIENT_ACCEPTED {
    set retry 0
}
when HTTP_REQUEST {
    set http_request [HTTP::request]
}
when HTTP_RESPONSE {
    if { ([HTTP::status] starts_with "4") || ([HTTP::status] starts_with "5")} {
        incr retry
        if { $retry <= [active_members [LB::server pool]] } {
            HTTP::retry $http_request
        } else {
            set retry 0
        }   
} else {
    set retry 0
}

}
when LB_SELECTED {
    log local0.info "Run $retry";
    if { ($retry > 0) && ($retry <= [active_members [LB::server pool]])} {
        LB::reselect pool [LB::server pool]
    }
}