You may be in luck... Or not... Too many unknowns to be sure...
The feature you're after is one-connect... But in order for it to multiplex correctly, I think it'll have to be HTTP traffic (Otherwise PTM won't know hoe to multiplex the request/response traffic to serialise it).
If it is HTTP, then configure the cone-connect with a mask of 0.0.0.0 (Means any client IP will match an existing server side connection and re-use it) and set the max connections of the node to 1 (So you don't get a second connection created).
Now.. I'm not 100% sure what will happen if the server-side connection is busy... (Sorry, not tried that scenario).
However even if those assumptions fail, as long as YOU can code in an iRule to differentiate between the request/response, then you could accept the request in the iRule, and process it yourself. Possibly with a sideband connection.
H