Spanning tree will sort itself out, AS LONG AS you have STP passthrough configured (Or if you know networks you could have the F5 do STP as well. But that's not always a simple config. You want to make sure you know exactly what's going to happen with your root bridge in all situations.
However you WILL get spanning tree reconvergences when doing this. Which means each VLAN (Assuming you're doing VLAN'ed spanning tree), every time you restart an F5. WHich isn't nice (30 second pause in the VLAN).
I like to avoid spanning tree whenever possible.
Oh... Don't try to get around the spanning tree by setting portfast... The F5 acts as a bridge. Portfast isn't a good idea through a bridge.
H
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