Hello, Mohanish
- Does the connection successfully establish if you issue "telnet Your.SSH.mgmt.IP 22"? Are there any return messages such as "Connection Refused" or "Connection Timed Out"?
One possibility is a crash of the SSH Daemon. You should try to restart the service with "bigstart restart sshd"; access your appliance Command Line either by using the physical serial connection cable, or try to access your device the via the AOM mgmt IP address (if you have configured it).
For restarting BigIP daemons via GUI, follow the instructions here: https://support.f5.com/kb/en-us/solutions/public/13000/400/sol13444.html
In the SOL article, scroll to: "Starting and stopping non-core daemons using the BIG-IP Configuration utility".