Hi Steve,
The switches in question are Nexus 7k's. So, C2400-01/Slot1 is connected directly to Switch_1. C2400-02/Slot1 is connected to Switch_2, but there is a VPC between the two Nexus switches.
I fear that if Switch_1 fails, I will lose the single slot guest on Slot1 in both chassis. Ideally, each blade needs to be multihomed to both switches to account for a switch failure like this. Currently, we have physical "internal" and "external" interfaces on each blade. I'm considering combining both internal & external into a single physical interface thus freeing up an additional 10GB switchport on the Nexus switches. This would allow me to multi-home each blade to each switch.
I believe there is a best practices document somewhere for Nexus+F5, I just need to dig it up.
Thanks