I'll try to answer some of your questions
The machine image ships with three total NICS:
1 "Flexible" for Management and 2 VMXNET3 for Traffic Management. E1000 is not supported.
The machine supports up to the maximum number of NICs that VMware supports for ESX and ESXi 4.0, which is ten.
It also supports the three tagging modes commonly used in vSphere deployments (VGT, VST, and most certainly EST)
They can belong to dvSwitch portgroups (theres no real difference between a dvSwitch portgroup and a vSwitch portgroup from the VM's perspective, but you may want to use static binding for faster failover)
BIG-IP VE 10.2 is licensed by throughput.
The VMXNET3 driver has been utilized for it's additional offload features. The VMXNET3 driver makes a difference in performance at the higher throughput levels.
Latency: While the hardware platforms that F5 sells are kings for throughput and reduction of latency, the Virtual Edition is no slouch. Paravirtualization, intelligent architecture and F5 know-how were extensively used in developing the Virtual Edition.
Jumbo Frames: No, this is not supported by the BIG-IP. See: https://support.f5.com/kb/en-us/solutions/public/6000/300/sol6399.html
More about this: There are documents available on askf5.com