Hi Starboy.
if it is the HTTP profile that poses a problem there is a good chance that you are not set up interception.
HTTPS communication is inside SSL encrypted tunnel. If you don't intercept/ decrypt traffic (usinc ssl client and ssl server) you won’t be able to read or write/manage HTTP content.
When you set your HTTP profil, you specify that the protocol is HTTP. But in your case you don't enable decryption so F5 (HTTP profil) can't detect the protocol because of encryption (TLS).
So in this case F5 reject connection.
So Enable decryption by setting Clientssl and serverssl.
Hope it's clear.
regards