Nimbostratus
MVPHi Giant,
the TCP-WAN-Optimized and TCP-LAN-Optimized profiles are not that gorgeous. The best suited default TCP profile for HTTP traffic is tcp-mobile-optimized even if you don't use mobile clients. This is even true for both client and server side profiles...
You may check the articles below to undertsand why the defaults profiles are as ****** as they are.... ;-)
Stop Using the Base TCP Profile!
https://devcentral.f5.com/articles/stop-using-the-base-tcp-profile
The short call to action is to stop using those old default profiles and switch to the new F5-* profiles. They are tweaked much better for the modern world...
F5 Unveils New Built-In TCP Profiles
https://devcentral.f5.com/articles/f5-unveils-new-built-in-tcp-profiles-25175
Further ressources if you want to handcraft a tailordered TCP profile...
Tuning the TCP Profile, Part One
https://devcentral.f5.com/articles/tuning-the-tcp-profile-part-one
Tuning the TCP Profile, Part Two
https://devcentral.f5.com/articles/tuning-the-tcp-profile-part-two-17857
Tuning the TCP Profile, Part Three
https://devcentral.f5.com/articles/tuning-the-tcp-profile-part-three-18526
The TCP Send Buffer, In-Depth
https://devcentral.f5.com/articles/the-send-buffer-in-depth-21845
The TCP Proxy Buffer
https://devcentral.f5.com/articles/the-tcp-proxy-buffer-22461
Cheers, Kai